BRAIN - Could Quantum Brain Effects Explain Consciousness?

NEW YORK — The idea that consciousness arises from quantum mechanical phenomena in the brain is intriguing, yet lacks evidence, scientists say.

Physicist Roger Penrose, of the University of Oxford, and anesthesiologist Stuart Hameroff, of the University of Arizona, propose that the brain acts as a quantum computer — a computational machine that makes use of quantum mechanical phenomena (like the ability of particles to be in two places at once) to perform complex calculations. In the brain, fibers inside neurons could form the basic units of quantum computation, Penrose and Hameroff explained at the Global Future 2045 International Congress, a futuristic conference held here June 15-16.

The idea is appealing, because neuroscience, so far, has no satisfactory explanation for consciousness — the state of being self-aware and having sensory experiences and thoughts. But many scientists are skeptical, citing a lack of experimental evidence for the idea. [Consciousness to Sleep: Top 10 Mysteries of the Mind]

The Orch OR model

Penrose and Hameroff developed their ideas independently, but collaborated in the early 1990s to develop what they call the Orchestrated Objective Reduction (Orch OR) model.

Penrose's work rests on an interpretation of the mathematician Kurt Godel'sincompleteness theorem, which states that certain results cannot be proven by a computer algorithm. Penrose argues that human mathematicians are capable of proving so-called "Godel-unprovable" results, and therefore human brains cannot be described as typical computers. Instead, he says, to achieve these higher abilities, brain processes must rely on quantum mechanics.

But Penrose's theory didn't explain how this quantum computing occurred inside actual brains, just that the phenomenon would be needed to solve certain mathematical equations. Hameroff read Penrose's work and suggested small fibrous structures that give cells their structural support — known as microtubules — might be capable of carrying out quantum computations.

Microtubules are made up of units of the protein tubulin, which contains regions where electrons are swirling around very close to each other. Hameroff proposed that these electrons could become "quantum entangled," a state in which two particles retain a connection, and an action performed on one affects the other, even when the two are separated by a distance.

In the Orch OR model, the mathematical probabilities that describe the quantum states of these entangled electrons in microtubules become unstable in space-time. These mathematical probabilities are called wave functions, and in this scenario they collapse, moving from a state of probability to a specific actuality. In this state, the microtubules in one neuron could be linked to those in other neurons via electrical connections known as gap junctions. These junctions would allow the electrons to "tunnel" to other regions of the brain, resulting in waves of neural activity that are perceived as conscious experience.

"Penrose had a mechanism for consciousness, and I had a structure," Hameroff told LiveScience.

Problems with the model

Interesting as it sounds, the Orch OR model has not been tested experimentally, and many scientists reject it.

Quantum computers — computers that take advantage of quantum mechanical effects to achieve extremely speedy calculations — have been theorized, but only one (built by the company D-Wave) is commercially available, and whether it's a true quantum computer is debated. Such computers would be extremely sensitive to perturbations in a system, which scientists refer to as "noise." In order to minimize noise, it's important to isolate the system and keep it very cold (because heat causes particles to speed up and generate noise).

Building quantum computers is challenging even under carefully controlled conditions. "This paints a desolate picture for quantum computation inside the wet and warm brain,” Christof Koch and Klaus Hepp, of the University of Zurich, Switzerland, wrote in an essay published in 2006 in the journal Nature.

Another problem with the model has to do with the timescales involved in the quantum computation. MIT physicist Max Tegmark has done calculations of quantum effects in the brain, finding that quantum states in the brain last far too short a time to lead to meaningful brain processing. Tegmark called the Orch OR model vague, saying the only numbers he’s seen for more concrete models are way off.

"Many people seem to feel that consciousness is a mystery and quantum mechanics is a mystery, so they must be related," Tegmark told LiveScience.

The Orch OR model draws criticism from neuroscientists as well. The model holds that quantum fluctuations inside microtubules produce consciousness. But microtubules are also found in plant cells, said theoretical neuroscientist Bernard Baars, CEO of the nonprofit Society for Mind-Brain Sciences in Falls Church, VA., who added, "plants, to the best of our knowledge, are not conscious."

These criticisms do not rule out quantum consciousness in principle, but withoutexperimental evidence, many scientists remain unconvinced.

"If somebody comes up with just one single experiment," to demonstrate quantum consciousness, Baars said, "I will drop all my skepticism."

Editor's Note: This article was updated on June 27, 2013 to amend the statement that "no quantum computers... have been realized." The company D-Wave claims to have created one, though some have questioned whether it really performs as a quantum computer.

Addendum: (July 1, 2013)

In response to the criticisms of the Orch OR model cited in this article, Stuart Hameroff offers several pieces of evidence. In reply to the objection that the brain is too warm for quantum computations, Hameroff cites a 2013 study led by Anirban Bandyopadhyay at the National Institute of Material Sciences (NIMS) in Tsukuba, Japan, which found that “microtubules become essentially quantum conductive when stimulated at specific resonant frequencies,” Hameroff said.

In reply to the criticism that microtubules are found in (unconscious) plant cells too, Hameroff said that plants have only a small number of microtubules, likely too few to reach the threshold needed for consciousness. But he also noted that Gregory Engel of the University of Chicago and colleagues have observed quantum effects in plant photosynthesis. “If a tomato or rutabaga can utilize quantum coherence at warm temperature, why can't our brains?” Hameroff said.

In response to general objections to a lack of evidence for his theory, Hameroff cited a 2013 study led Rod Eckenhoff at the University of Pennsylvania that suggests that anesthetics – which stop only conscious brain activity – act via microtubules.

These studies lend some support to the Orch OR model. But as with all scientific hypotheses, the model must accumulate significant evidence in order to earn widespread acceptance among the scientific community.